Repeatability of regional pulmonary functional metrics of Hyperpolarized 129 Xe dissolved‐phase MRI
نویسندگان
چکیده
منابع مشابه
Oxygen-dependent hyperpolarized (129) Xe brain MR.
Hyperpolarized (HP) (129) Xe MR offers unique advantages for brain functional imaging (fMRI) because of its extremely high sensitivity to different chemical environments and the total absence of background noise in biological tissues. However, its advancement and applications are currently plagued by issues of signal strength. Generally, xenon atoms found in the brain after inhalation are trans...
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Ex vivo rodent lung models are explored for physiological measurements of respiratory function with hyperpolarized (hp) (129)Xe MRI. It is shown that excised lung models allow for simplification of the technical challenges involved and provide valuable physiological insights that are not feasible using in vivo MRI protocols. A custom designed breathing apparatus enables MR images of gas distrib...
متن کاملMotion-corrected pO2 mapping in human lungs using hyperpolarized Xe-129 MRI
Background: T1-weighted imaging of inhaled hyperpolarized gas can be used to quantify the partial pressure of oxygen (pO2) in lung airspaces. A short-breath-hold implementation of the pO2-mapping technique, using hyperpolarized He, was shown to accurately depict known pO2 variations in phantom experiments, and yielded physiologically plausible pO2 maps in human lungs [1]. Although most pO2 mapp...
متن کاملComparison of 3 He and 129 Xe MRI for evaluation of lung microstructure and ventilation at 1.5T.
BACKGROUND To support translational lung MRI research with hyperpolarized 129 Xe gas, comprehensive evaluation of derived quantitative lung function measures against established measures from 3 He MRI is required. Few comparative studies have been performed to date, only at 3T, and multisession repeatability of 129 Xe functional metrics have not been reported. PURPOSE/HYPOTHESIS To compare hy...
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S. S. Kaushik, Z. I. Cleveland, G. P. Cofer, G. Metz, D. Beaver, J. Nouls, M. Kraft, J. Wolber, H. P. McAdams, and B. Driehuys Center for In-Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, Radiology, Duke University Medical Center, Durham, NC, United States, Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC, United States, GE Healthcare...
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ژورنال
عنوان ژورنال: Journal of Magnetic Resonance Imaging
سال: 2019
ISSN: 1053-1807,1522-2586
DOI: 10.1002/jmri.26745